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data-draft-node=\"inline\" data-draft-type=\"reference\" data-numero=\"1\" data-text=\"https:\/\/doi.org\/10.1016\/j.cell.2023.10.025\" data-url=\"\">[1]<\/sup>\uff1a\u5efa\u7acb\u4e86\u5c0f\u9f20\u7761\u7720\u5265\u593a\u7684\u9ad8\u6548\u6a21\u578b\uff1b\u7761\u7720\u5265\u593a\u589e\u5f3a\u4e86PGD2\uff08\u524d\u5217\u817a\u7d20D2\uff09\u5206\u5b50\u6d41\u7a7f\u8fc7BBB\uff08\u8840\u8111\u5c4f\u969c\uff09\uff1b\u7761\u7720\u5265\u593a\u8bf1\u53d1\u7ec6\u80de\u56e0\u5b50\u548c\u5faa\u73af\u4e2d\u6027\u7c92\u7ec6\u80de\u589e\u52a0\uff1b\u88ab\u5265\u593a\u7761\u7720\u7684\u5927\u8111\u901a\u8fc7PGD2\/DP1\u8f74\u5f71\u54cd\u5916\u5468\u514d\u75ab\u7cfb\u7edf\u3002<\/p>\n<p><img decoding=\"async\" data-src=\"https:\/\/pica.zhimg.com\/50\/v2-3bc64a1ce2330d65745decd9d068ba61_720w.jpg?source=1def8aca\" src=\"https:\/\/pica.zhimg.com\/50\/v2-3bc64a1ce2330d65745decd9d068ba61_720w.jpg?source=1def8aca\"\/><figcaption>https:\/\/doi.org\/10.1016\/j.cell.2023.10.025<\/figcaption><p>\u8fd9\u91cc\u9762\u5f88\u591a\u795e\u7ecf\u751f\u7269\u5b66\u548c\u514d\u75ab\u5b66\u7684\u4e1c\u897f\uff0c\u6211\u7ffb\u8bd1\u7684\u53ef\u80fd\u4e0d\u592a\u6b63\u786e\uff1b\u770b\u56fe\u5176\u5b9e\u6bd4\u8f83\u660e\u767d\uff0c\u7761\u7720\u5265\u593a\u4e0d\u4ec5\u4ec5\u5f71\u54cd\u4e86\u5927\u8111\uff0c\u4e5f\u901a\u8fc7\u5927\u8111\u5206\u6ccc\u7684\u6fc0\u7d20\u5f71\u54cd\u514d\u75ab\u7cfb\u7edf\uff1b\u79ef\u7d2f\u5230\u4e00\u5b9a\u7a0b\u5ea6\u7684\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\uff08proinflammatory cytokine\uff09\u79ef\u7d2f\u540e\uff0c\u6700\u7ec8\u4f1a\u653b\u51fb\u810f\u5668\uff0c\u5927\u81f4\u5404\u79cd\u75be\u75c5\u53d1\u751f\u3002<\/p>\n<p>\u4f5c\u8005\u6bd4\u8f83\u770b\u91cd\u7684\u4e00\u4e2a\u6a21\u578b\u5982\u4e0b\uff0c\u901a\u8fc7\u6c34\u6765\u963b\u6b62\u5c0f\u9f20\u7761\u7720<sup data-draft-node=\"inline\" data-draft-type=\"reference\" data-numero=\"2\" data-text=\"Sang et al., 2023, Cell 186, 1\u201317\" data-url=\"\">[2]<\/sup>\uff1a<\/p>\n<p><img decoding=\"async\" data-src=\"https:\/\/picx.zhimg.com\/50\/v2-4b2f593c8728156553d29c8dbc0b0fd9_720w.jpg?source=1def8aca\" src=\"https:\/\/picx.zhimg.com\/50\/v2-4b2f593c8728156553d29c8dbc0b0fd9_720w.jpg?source=1def8aca\"\/><figcaption>Sang et al., 2023, Cell 186, 1\u201317<\/figcaption><p>\u8fd9\u91cc\u9762\u6bd4\u8f83\u6709\u610f\u601d\u7684\u662f\uff0c\u7761\u7720\u5265\u593a\u7ec4\uff08SD\uff09\u660e\u663e\u662f\u6ca1\u6709\u975e\u5feb\u52a8\u773c\u7761\u7720\uff08NREMS\uff09\u7684\uff0c\u800c\u6b63\u5e38\u7ec4\uff08Con\uff09\u548c\u8f7b\u5ea6\u7f3a\u89c9\uff08\u7f3a99\u5206\u949f\u621616%\uff09\uff08eCon\uff09\u4e0e\u6b63\u5e38\u6ca1\u6709\u591a\u5c11\u533a\u522b\u3002<\/p>\n<p><img decoding=\"async\" data-src=\"https:\/\/picx.zhimg.com\/50\/v2-f9be8d383ffa97f71787e962766bff60_720w.jpg?source=1def8aca\" src=\"https:\/\/picx.zhimg.com\/50\/v2-f9be8d383ffa97f71787e962766bff60_720w.jpg?source=1def8aca\"\/><\/p>\n<p>\u4ec5\u4ece\u8fd9\u4e2a\u6307\u6807\u6765\u770b\uff0c\u4e5f\u5c31\u662f\u5076\u5c14\u71ac\u4e2a\u591c\u6216\u8005\u52a0\u4e2a\u73ed\uff0c\u5e94\u8be5\u5bf9\u8eab\u4f53\u8d1f\u62c5\u6bd4\u8f83\u5c0f\uff0c\u9002\u5408\u62d6\u5ef6\u75c7\u60a3\u8005\u5076\u5c14\u52a0\u73ed\u554a\uff1a\uff09<\/p>\n<p>\u6545\u4e8b\u903b\u8f91\u7ebf\u5f88\u6e05\u695a\uff0c\u6211\u4e0d\u662f\u8fd9\u4e2a\u4e13\u4e1a\uff0c\u4e5f\u4e0d\u61c2\u6570\u636e\u7ec6\u8282\u3002\u8fd8\u662f\u90a3\u53e5\u8bdd\uff0c\u4ee5\u4e0a\u6570\u636e\u90fd\u662f\u57fa\u4e8e\u5c0f\u9f20\uff0c\u6240\u4ee5\u672a\u5fc5\u5b8c\u5168\u5728\u4eba\u8eab\u4e0a\u590d\u5236\u3002\u4f46\u662f\u4e0d\u7ba1\u600e\u4e48\u6837\uff0c\u7761\u7720\u4e00\u5b9a\u662f\u975e\u5e38\u91cd\u8981\u7684\uff0c\u8fd9\u4e2a\u5373\u4f7f\u6ca1\u6709\u7406\u8bba\u652f\u6301\uff0c\u6240\u6709\u4eba\u90fd\u662f\u77e5\u9053\u7684\uff0c\u6240\u4ee5\u5343\u4e07\u522b\u8001\u7f3a\u89c9\uff01<\/p>\n<p>\u3010\u793a\u610f\u56fe\u91cc\u9762\uff0cIL-6\uff0cIL-17\u548cCXCL1\u90fd\u662f\u7ec6\u80de\u56e0\u5b50\uff0c\u9776\u70b9\u5176\u5b9e\u90fd\u4e0d\u53ea\u662f\u4e2d\u6027\u7c92\u7ec6\u80de\uff1b\u4f5c\u8005\u89e3\u91ca\u6216\u8005\u8bf4\u68c0\u6d4b\u5230\u4e09\u8005\u4e0a\u8c03\uff0c\u4ece\u800c\u6fc0\u6d3b\u4e86\u66f4\u591a\u7684\u4e2d\u6027\u7c92\u7ec6\u80de\uff0c\u4e2d\u6027\u7c92\u7ec6\u80de\u8fc7\u591a\u589e\u52a0\uff0c\u53ef\u80fd\u65e0\u5dee\u522b\u541e\u566c\u4e86\u7ec4\u7ec7\u7ec6\u80de\uff0c\u4ece\u800c\u5bfc\u81f4\u7ec4\u7ec7\u5668\u5b98\u7834\u574f\uff0c\u4f30\u8ba1\u5c31\u662f\u8fd9\u4e48\u4e00\u4e2a\u89e3\u91ca\u3002\u3011<\/p>\n<p>\u81f3\u4e8e\u7761\u7720\u7684\u5371\u5bb3\uff0c\u5f15\u7528\u4e0b\u536b\u5065\u59d4\u7684\u5427<sup data-draft-node=\"inline\" data-draft-type=\"reference\" data-numero=\"3\" data-text=\"\" data-url=\"https:\/\/www.gov.cn\/xinwen\/2019-07\/23\/content_5413376.htm#:~:text=\u6700\u65b0\u7814\u7a76\u8868\u660e\uff0c\u957f\u671f\u7761\u7720\u4e0d\u8db3\u4f1a\u52a0\u5927\u60a3\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u3001\u6291\u90c1\u75c7\u3001\u7cd6\u5c3f\u75c5\u548c\u80a5\u80d6\u7684\u98ce\u9669\uff0c\u635f\u5bb3\u8ba4\u77e5\u529f\u80fd\u3001\u8bb0\u5fc6\u529b\u548c\u514d\u75ab\u7cfb\u7edf%E3%80%82,\u4e0e\u7761\u7720\u76f8\u5173\u75be\u75c5\u670980\u591a\u79cd%E3%80%82%20\u4e13\u5bb6\u6307\u51fa\uff0c\u6210\u5e74\u4eba\u4fdd\u63017\u52308\u4e2a\u5c0f\u65f6\u7761\u7720\u662f\u6709\u79d1\u5b66\u4f9d\u636e\u7684\uff0c\u5bf9\u5065\u5eb7\u4e5f\u662f\u6700\u6709\u5229\u7684%E3%80%82\">[3]<\/sup>\uff1a<\/p>\n<blockquote><p>\u6700\u65b0\u7814\u7a76\u8868\u660e\uff0c\u957f\u671f\u7761\u7720\u4e0d\u8db3\u4f1a\u52a0\u5927\u60a3\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u3001\u6291\u90c1\u75c7\u3001\u7cd6\u5c3f\u75c5\u548c\u80a5\u80d6\u7684\u98ce\u9669\uff0c\u635f\u5bb3\u8ba4\u77e5\u529f\u80fd\u3001\u8bb0\u5fc6\u529b\u548c\u514d\u75ab\u7cfb\u7edf\u3002\u4e0e\u7761\u7720\u76f8\u5173\u75be\u75c5\u670980\u591a\u79cd\u3002<\/p><\/blockquote>\n<h2>\u56de\u7b54\u4f5c\u8005\uff1a\u65b9\u53ef<\/h2>\n<p>\u8fd9\u9879\u7814\u7a76\u662f\u5bf9\u5c0f\u9f20\u5f15\u5165\u4e86 \u4e00\u79cd\u5168\u65b0\u7684\u540d\u4e3a\u201cCurling Prevention by Water\u201d\uff08CPW\uff09\u7684\u7761\u7720\u5265\u593a\u7cfb\u7edf\uff0c\u8be5\u7cfb\u7edf\u53ef\u4ee5\u6301\u7eed\u5265\u593a\u5c0f\u9f2095%\u4ee5\u4e0a\u7684\u7761\u7720\uff0c\u80fd\u591f\u66f4\u6709\u6548\u5730\u8bf1\u5bfc\u5c0f\u9f20\u7761\u7720\u5265\u593a\u3002<\/p>\n<p><img decoding=\"async\" data-src=\"https:\/\/pica.zhimg.com\/50\/v2-30b4c520ec86e32ef6b89cc17d31025a_720w.jpg?source=1def8aca\" src=\"https:\/\/pica.zhimg.com\/50\/v2-30b4c520ec86e32ef6b89cc17d31025a_720w.jpg?source=1def8aca\"\/><\/p>\n<p>\u501f\u52a9\u5168\u65b0\u7684CPW\u7cfb\u7edf\uff0c\u7814\u7a76\u8005\u5bf9\u5c0f\u9f20\u8fdb\u884c\u957f\u65f6\u95f4\u7761\u7720\u5265\u593a\u65f6\u53d1\u73b0\uff0c\u53d1\u73b0<b>\u957f\u671f\u7761\u7720\u5265\u593a\u53ef\u5f15\u53d1\u5c0f\u9f20\u81f4\u547d\u7684\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\u6837\u7efc\u5408\u5f81\uff0c\u5e76\u5bfc\u81f4\u8fc7\u65e9\u6b7b\u4ea1<\/b>\u3002<\/p>\n<p>\u6309\u7167\u4f20\u7edf\u7684\u7406\u89e3\uff0c\u7761\u7720\u7f3a\u4e4f\u5bfc\u81f4\u7684\u514d\u75ab\u7cfb\u7edf\u7684\u53d8\u5316\u662f\u514d\u75ab\u529f\u80fd\u4e0b\u964d\uff0c\u8eab\u4f53\u6297\u611f\u67d3\u7684\u80fd\u529b\u4e0b\u964d\uff0c\u66f4\u5bb9\u6613\u53d7\u5916\u754c\u7ec6\u83cc\u6216\u75c5\u6bd2\u611f\u67d3\u3002\u7814\u7a76\u4eba\u5458\u505a\u4e86\u4e24\u9879\u8bd5\u9a8c\uff1a\u4e00\u662f\u5728\u7761\u7720\u5265\u593a\u8fc7\u7a0b\u4e2d\uff0c\u4e3a\u5c0f\u9f20<b>\u63d0\u4f9b\u6297\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\u836f\u7269\uff0c<\/b>\u80fd\u591f\u7f13\u548c\u7761\u7720\u5265\u593a\u5bfc\u81f4\u7684\u514d\u75ab\u53cd\u5e94\u5e76\u5ef6\u957f\u5c0f\u9f20\u7684\u5b58\u6d3b\u65f6\u95f4\u3002\u4e8c\u662f\u5c06\u91ce\u751f\u578b\u5c0f\u9f20\u66ff\u6362\u4e3a<b>\u514d\u75ab\u7f3a\u9677\u54c1\u7cfb(M-NSG)<\/b>\u5c0f\u9f20\u3002M-NSG\u5c0f\u9f20\u5e76\u6ca1\u6709\u56e0\u4e3a\u514d\u75ab\u529b\u5f31\uff0c\u800c\u7531\u5916\u754c\u75c5\u539f\u4f53\u611f\u67d3\u800c\u66f4\u5feb\u5730\u6b7b\u4ea1\u3002\u5bf9\u8fd9\u79cd\u5c0f\u9f20\u8fdb\u884c\u957f\u8fbe\u4e00\u5468\u7684\u7761\u7720\u5265\u593a\u90fd\u4e0d\u4f1a\u6709\u4e2a\u4f53\u6b7b\u4ea1\u3002\u8bf4\u660e\u4e86\u4e0d\u7761\u89c9\u5bfc\u81f4\u7684\u6b7b\u4ea1\u771f\u6b63\u539f\u56e0\u662f\u514d\u75ab\u7cfb\u7edf\u7684\u8fc7\u5ea6\u6fc0\u6d3b\u3002<\/p>\n<p>\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u7761\u7720\u5265\u593a\u5bfc\u81f4\u7684\u514d\u75ab\u53cd\u5e94\u662f\u7531PGD2 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decoding=\"async\" data-src=\"https:\/\/picx.zhimg.com\/50\/v2-f95292f57642da237c9d43f96748fe80_720w.jpg?source=1def8aca\" src=\"https:\/\/picx.zhimg.com\/50\/v2-f95292f57642da237c9d43f96748fe80_720w.jpg?source=1def8aca\"\/><figcaption>https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0092867423011765-fx1_lrg.jpg<\/figcaption><p>\u901a\u8fc7\u4e00\u7cfb\u5217\u52a8\u7269\u5b9e\u9a8c\uff0c\u7814\u7a76\u663e\u793a\uff0c\u7761\u7720\u5265\u593a\u589e\u52a0\u4e86\u8111\u5185\u524d\u5217\u817a\u7d20prostaglandin D2(PGD2) 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data-draft-node=\"inline\" data-draft-type=\"reference\" data-numero=\"2\" data-text=\"\" data-url=\"https:\/\/www.nhlbi.nih.gov\/health\/sleep-deprivation\/health-effects\">[2]<\/sup><sup data-draft-node=\"inline\" data-draft-type=\"reference\" data-numero=\"3\" data-text=\"\" data-url=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5449130\/\">[3]<\/sup><sup data-draft-node=\"inline\" data-draft-type=\"reference\" data-numero=\"4\" data-text=\"\" data-url=\"https:\/\/www.nature.com\/articles\/s42003-021-02825-4\">[4]<\/sup><sup data-draft-node=\"inline\" data-draft-type=\"reference\" data-numero=\"5\" data-text=\"\" data-url=\"https:\/\/www.hopkinsmedicine.org\/health\/conditions-and-diseases\/sleep-deprivation\">[5]<\/sup><sup data-draft-node=\"inline\" data-draft-type=\"reference\" data-numero=\"6\" data-text=\"\" 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