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src=\"https:\/\/picx.zhimg.com\/50\/v2-b8d5f22f47c243a1d6d818b74cab531f_720w.jpg?source=1def8aca\"\/><\/p>\n<p><b>\u8d8a\u6765\u8d8a\u591a\u7684\u6211\u4eec\u5c31\u662f\u8fd9\u6837\uff0c\u559d\u7740\u67b8\u675e\uff0c\u5374\u53eb\u7740\u6cb9\u817b\u7684\u5916\u5356\uff1b\u6577\u7740\u9762\u819c\uff0c\u5374\u7ee7\u7eed\u71ac\u7740\u6700\u6df1\u7684\u591c\u3002<\/b><\/p>\n<p><b>\u5f53\u7136\u4e86\u4e5f\u6709\u5f88\u591a\u7531\u4e8e\u5de5\u4f5c\u548c\u5b66\u4e60\u9700\u8981\uff0c\u88ab\u52a8\u7684\u5728\u71ac\u591c\u3002<\/b><\/p>\n<p>\u65e2\u7136\u6ce8\u5b9a\u8981\u71ac\u591c\u4e86\uff0c\u90a3\u600e\u4e48\u51cf\u5c11\u71ac\u591c\u7684\u4f24\u5bb3\u5462\uff1f<\/p>\n<p>1\u3001\u6709\u8ba1\u5212\u71ac\u591c\u524d<\/p>\n<p>\u77e5\u9053\u54ea\u5929\u8981\u71ac\u591c\u7684\u8bdd\uff0c\u5728\u71ac\u591c\u524d\u53ef\u4ee5\u591a\u7761\u4e00\u4f1a\uff0c\u53ef\u4ee5\u51cf\u8f7b\u71ac\u591c\u5e26\u6765\u7684\u4f24\u5bb3\u3002<\/p>\n<p>2\u3001\u71ac\u591c\u4e2d<\/p>\n<ul>\n<li>\u5c11\u5403\u96f6\u98df<\/li>\n<li>\u591a\u559d\u6c34<\/li>\n<li>\u4e0d\u62bd\u70df\u559d\u9152<\/li>\n<li>\u6700\u597d\u5c0f\u7761\u4e00\u4f1a<\/li>\n<\/ul>\n<p>3\u3001\u71ac\u591c\u540e<\/p>\n<ul>\n<li>\u8865\u89c9<\/li>\n<\/ul>\n<p>\u867d\u7136\u8865\u89c9\u5e76\u4e0d\u80fd\u5f25\u8865\u71ac\u591c\u6240\u5e26\u6765\u7684\u5371\u5bb3\uff0c\u4f46\u662f\u53ef\u4ee5\u51cf\u5c11\u75b2\u52b3\uff0c\u8ba9\u8eab\u4f53\u72b6\u6001\u597d\u4e00\u4e9b\u3002<\/p>\n<ul>\n<li>\u907f\u514d\u5267\u70c8\u8fd0\u52a8<\/li>\n<\/ul>\n<p>\u71ac\u591c\u540e\u5728\u5267\u70c8\u8fd0\u52a8\u5bb9\u6613\u51fa\u73b0\u731d\u6b7b\u7b49\u610f\u5916\u4e8b\u4ef6\u3002<\/p>\n<p><\/p>\n<p><b>\u3010\u71ac\u591c\u4e00\u65f6\u723d\uff0c\u5927\u8111\u706b\u846c\u573a\u3011\uff0c\u6240\u4ee5\u4f60\u8fd8\u8981\u71ac\u591c\u5417.........<\/b><\/p>\n<p><img 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target=\"_blank\">JACC\uff1a\u4e00\u5b9a\u8981\u7761\u591f7\u5c0f\u65f6\uff01\u79d1\u5b66\u5bb6\u9996\u6b21\u53d1\u73b0\uff0c\u4e0e\u77617-8\u5c0f\u65f6\u76f8\u6bd4\uff0c\u7761\u4e0d\u591f6\u5c0f\u65f6\u5168\u8eab\u52a8\u8109\u8840\u7ba1\u7ca5\u6837\u786c\u5316\u6591\u5757\u5f62\u6210\u98ce\u9669\u589e27%\u4e28\u4e34\u5e8a\u5927\u53d1\u73b0<\/a><\/p>\n<p>2\uff0c\u7761\u7720\u5bf9\u4eba\u7684\u610f\u4e49\u4e1d\u6beb\u4e0d\u4e9a\u4e8e\u98df\u7269\u548c\u6c34\u3002\u65e0\u8bba\u6709\u591a\u4e48\u75b2\u60eb\u548c\u5fe7\u8651\uff0c\u53ea\u8981\u7f8e\u7f8e\u5730\u7761\u4e0a\u4e00\u987f\uff0c\u53c8\u80fd\u8ba9\u4eba\u6ee1\u8840\u590d\u6d3b\u4e86\u3002\u8fd8\u662f\u653e\u4e2a\u94fe\u63a5\uff0c\u76f8\u5173\u7684\u7814\u7a76\u8bba\u6587\u633a\u6709\u610f\u601d\u7684\uff0c\u6211\u76f8\u4fe1\u77e5\u4e4e\u7528\u6237\u7684\u77e5\u8bc6\u6c34\u5e73\u9605\u8bfb\u8d77\u6765\u4e0d\u4f1a\u6709\u95ee\u9898\u3002<\/p>\n<p><a data-draft-node=\"block\" data-draft-type=\"link-card\" href=\"https:\/\/link.zhihu.com\/?target=https%3A\/\/mp.weixin.qq.com\/s\/LeSYaFc7FqCnBFxzCQG0wg\" rel=\"nofollow noreferrer\" target=\"_blank\">\u300a\u81ea\u7136\u300b\uff1a\u95f4\u65ad\u6027\u7761\u7720\u6bc1\u8840\u7ba1\uff01\u54c8\u4f5b\u79d1\u5b66\u5bb6\u53d1\u73b0\uff0c\u788e\u7247\u5316\u7761\u7720\u5bfc\u81f4\u767d\u7ec6\u80de\u589e\u591a\uff0c\u7834\u574f\u8840\u7ba1\u5185\u58c1\uff0c\u8bf1\u53d1\u52a8\u8109\u7ca5\u6837\u786c\u5316\u4e28\u79d1\u5b66\u5927\u53d1\u73b0<\/a><\/p>\n<p>3\uff0c\u4e07\u7269\u7686\u6709\u8282\u5f8b\uff0c\u4eba\u4e5f\u4e00\u6837\u3002\u4e0d\u7ba1\u662f\u6211\u4eec\u7684\u5185\u5206\u6ccc\u7cfb\u7edf\u8fd8\u662f\u795e\u7ecf\u7cfb\u7edf\uff0c\u5305\u62ec\u6211\u4eec\u7684\u9f3b\u8154\u901a\u6c14\uff0c\u90fd\u6709\u81ea\u8eab\u7684\u8282\u5f8b\u3002\u7814\u7a76\u8868\u660e\uff0c<b>\u8be5\u7761\u89c9\u7684\u65f6\u5019\u4e0d\u7761\uff0c\u4f1a\u7834\u574f\u4eba\u4f53\u5185\u80be\u4e0a\u817a\u7d20\u7b49\u7684\u663c\u591c\u8282\u5f8b<\/b>\uff0c\u5bfc\u81f4\u5176\u6c34\u5e73\u5f02\u5e38\u5347\u9ad8\uff0c<b>\u6291\u5236T\u7ec6\u80de\u5bf9\u9776\u6807\u7684\u7c98\u9644\u80fd\u529b\uff0cT\u7ec6\u80de\u548c\u6297\u539f\u7ed3\u5408\u53d7\u5230\u5f71\u54cd\uff0c\u5f71\u54cd\u6b63\u5e38\u514d\u75ab\u529f\u80fd\u3002\u7f3a\u5c11\u7761\u7720\u7684\u4eba\u66f4\u5bb9\u6613\u611f\u5192\uff0c\u751a\u81f3\u8111\u5352\u4e2d\u3002<\/b><\/p>\n<p><a data-draft-node=\"block\" data-draft-type=\"link-card\" href=\"https:\/\/link.zhihu.com\/?target=https%3A\/\/mp.weixin.qq.com\/s\/tw4D-zSyY0160OO36-CmvA\" rel=\"nofollow noreferrer\" target=\"_blank\">\u71ac\u591c\u4e0d\u7761\uff0c\u514d\u75ab\u5d29\u6e83\uff01\u79d1\u5b66\u7814\u7a76\u8868\u660e\uff0c\u71ac\u591c\u4f1a\u5bfc\u81f4\u524d\u5217\u817a\u7d20\u7b49\u6fc0\u7d20\u5206\u6ccc\u7d0a\u4e71\uff0c\u8fdb\u800c\u6291\u5236T\u7ec6\u80de\u6d88\u706d\u5165\u4fb5\u75c5\u539f\u7269\u4e28\u79d1\u5b66\u5927\u53d1\u73b0<\/a><\/p>\n<h2>\u56de\u7b54\u4f5c\u8005\uff1a\u7533\u6668\u715c<\/h2>\n<ul>\n<li>\u71ac\u591c\u7684\u672c\u8d28\u662f\u201c\u81ea\u6211\u638c\u63a7\u611f\u201d\u3002<\/li>\n<\/ul>\n<p>\u201c\u5de5\u5177\u4eba\u201d\u3001\u201c\u6253\u5de5\u4eba\u201d\u7684\u8eab\u4efd\u8ba9\u6211\u4eec\u767d\u5929\u7684\u65f6\u95f4\u5b8c\u5168\u88ab\u5176\u4ed6\u4e8b\u60c5\u6240\u5360\u636e\uff0c\u53ea\u6709\u665a\u4e0a\u7684\u7247\u523b\u65f6\u95f4\u624d\u80fd\u5b8c\u5168\u5c5e\u4e8e\u81ea\u5df1\uff0c\u5237\u5237\u624b\u673a\u3001\u770b\u770b\u77ed\u89c6\u9891\u3001\u8ddf\u5f02\u5730\u7684\u5973\u670b\u53cb\u804a\u804a\u5929\uff0c\u8fd9\u624d\u662f\u771f\u6b63\u7684\u751f\u6d3b\uff0c\u6240\u4ee5\u4e0d\u662f\u7761\u4e0d\u7740\uff0c\u800c\u662f\u6839\u672c\u4e0d\u820d\u5f97\u5165\u7761\u3002<\/p>\n<p>\u53e6\u5916\uff0c\u6211\u4eec\u65f6\u5e38\u7ecf\u5386\u4e00\u4e9b\u6709\u201c\u632b\u8d25\u611f\u201d\u7684\u4e8b\u60c5\uff0c\u5f88\u5bb9\u6613\u53d1\u73b0\u81ea\u5df1\u8106\u5f31\u65e0\u529b\u7684\u4e00\u9762\uff0c\u8fd9\u4e2a\u90e8\u5206\u96be\u4ee5\u8ba9\u4eba\u63a5\u53d7\uff0c\u56e0\u4e3a\u5b83\u4f1a\u8ba9\u4eba\u4ea7\u751f\u5f3a\u70c8\u7684\u201c\u5931\u63a7\u611f\u201d\u548c\u201c\u65e0\u80fd\u611f\u201d\u3002\u56e0\u800c\u6211\u4eec\u60f3\u8981\u638c\u63a7\u4e00\u4e9b\u4e8b\u60c5\uff0c\u6bd4\u5982\u201c\u60f3\u7761\u5c31\u7761\uff0c\u60f3\u71ac\u591c\u5c31\u71ac\u591c\u201d\uff0c\u901a\u8fc7\u81ea\u6211\u63a7\u5236\u6765\u7f13\u89e3\u201c\u5931\u63a7\u201d\u548c\u201c\u65e0\u80fd\u201d\u5e26\u6765\u7684\u8d1f\u9762\u4f53\u9a8c\u3002<\/p>\n<p>\u95ee\u9898\u7684\u5173\u952e\u5728\u4e8e\u6211\u4eec\u4e3a\u4f55\u4f1a\u628a\u201c\u632b\u8d25\u611f\u201d\u8ddf\u201c\u5931\u63a7\u201d\u8054\u7cfb\u8d77\u6765\uff1f<\/p>\n<p>\u8fd9\u53ef\u80fd\u4e0e\u6210\u957f\u73af\u5883\u76f8\u5173\uff0c\u6211\u4eec\u4f1a\u8ba4\u4e3a\u53ea\u6709\u5728\u7b26\u5408\u65c1\u4eba\u7684\u671f\u5f85\u4e4b\u540e\u624d\u80fd\u5f97\u5230\u8ba4\u53ef\uff0c\u6bd4\u5982\u8003\u8bd5\u6210\u7ee9\u4f18\u5f02\u3001\u6bd4\u540c\u9f84\u4eba\u66f4\u4f18\u79c0\u7b49\u7b49\u3002\u800c\u4e00\u65e6\u72af\u9519\uff0c\u5c31\u4f1a\u906d\u53d7\u6307\u8d23\u3002\u6211\u4eec\u6162\u6162\u4e60\u60ef\u4e8e\u5bdf\u8a00\u89c2\u8272\uff0c\u53d8\u5f97\u4e0d\u5141\u8bb8\u81ea\u5df1\u51fa\u9519\u3002\u4e45\u800c\u4e45\u4e4b\uff0c\u751a\u81f3\u5185\u5316\u4e3a\u4eba\u751f\u4fe1\u6761\u2014\u2014\u6211\u5fc5\u987b\u8db3\u591f\u597d\u3001\u8db3\u591f\u5b8c\u7f8e\uff0c\u6211\u624d\u662f\u88ab\u8ba4\u53ef\u7684\uff0c\u624d\u662f\u6709\u4ef7\u503c\u7684\u3002\u4e00\u65e6\u6709\u4e8b\u60c5\u6ca1\u6709\u6309\u7167\u9884\u671f\u53d1\u5c55\uff0c\u5c31\u4f1a\u6709\u5f3a\u70c8\u5730\u4e0d\u88ab\u63a5\u7eb3\u548c\u8ba4\u53ef\u7684\u611f\u89c9\u3002<\/p>\n<p>\u56e0\u6b64\u6211\u4eec\u5fc5\u987b\u63a7\u5236\u81ea\u5df1\u7684\u4eba\u751f\uff0c\u533a\u533a\u4e00\u4e2a\u7761\u7720\u66f4\u5e94\u4e0d\u5728\u8bdd\u4e0b\uff0c\u4f46\u4eba\u751f\u6d69\u701a\uff0c\u4f60\u80fd\u63a7\u5236\u7684\u90e8\u5206\u5be5\u5be5\u65e0\u51e0\u3002<\/p>\n<p><img decoding=\"async\" data-src=\"https:\/\/pic1.zhimg.com\/50\/v2-2a7e00d7bf6df874b2a5544254428116_720w.jpg?source=1def8aca\" src=\"https:\/\/pic1.zhimg.com\/50\/v2-2a7e00d7bf6df874b2a5544254428116_720w.jpg?source=1def8aca\"\/><\/p>\n<ul>\n<li>\u71ac\u591c\u7684\u98ce\u9669\uff1a2020\u5e746\u67084\u65e5\uff0c\u7f8e\u56fd\u54c8\u4f5b\u533b\u5b66\u9662\u7684\u795e\u7ecf\u79d1\u5b66\u5bb6\u5728<i>Cell<\/i>\u6742\u5fd7\u53d1\u8868\u8bba\u6587<sup data-draft-node=\"inline\" data-draft-type=\"reference\" data-numero=\"1\" data-text=\"Vaccaro A , Dor Y K , Nambara K , et al. Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut[J]. Cell, 2020, 181(6).\" data-url=\"\">[1]<\/sup>\uff0c\u53d1\u73b0\u7761\u7720\u5265\u593a\u4f1a\u5bfc\u81f4\u679c\u8747\u7684\u80a0\u9053\u5185\u84c4\u79ef\u8fc7\u91cf\u7684\u6c27\u5316\u6d3b\u6027\u7269\u8d28\uff08Reactive Oxygen Species, ROS\uff09\uff0c\u4ece\u800c\u5bfc\u81f4\u679c\u8747\u6b7b\u4ea1\uff0c\u4f46\u53ea\u8981\u4e2d\u548c\u6389\u8fd9\u4e9b\u6d3b\u6027\u6c27\uff0c\u679c\u8747\u5c31\u7b97\u4e0d\u7761\u89c9\u4e5f\u80fd\u5b58\u6d3b\u3002<\/li>\n<\/ul>\n<p><img decoding=\"async\" data-src=\"https:\/\/picx.zhimg.com\/50\/v2-2ad5fda4b793e7374337b927dd0fb5fa_720w.jpg?source=1def8aca\" src=\"https:\/\/picx.zhimg.com\/50\/v2-2ad5fda4b793e7374337b927dd0fb5fa_720w.jpg?source=1def8aca\"\/><figcaption>1\u3001\u7761\u7720\u5265\u593a\u4f1a\u4f7f\u679c\u8747\u548c\u5927\u9f20\u7684\u80a0\u9053\u5185ROS\u8fc7\u91cf\u7d2f\u79ef\uff1b2\u3001\u80a0\u9053\u5185\u84c4\u79ef\u7684ROS\u53ef\u8bf1\u53d1\u76f8\u5e94\u7ec4\u7ec7\u5668\u5b98\u5185\u7684\u6c27\u5316\u5e94\u6fc0\u53cd\u5e94\uff1b3\u3001\u9632\u6b62ROS\u5728\u80a0\u9053\u5185\u84c4\u79ef\uff0c\u5373\u4f7f\u679c\u8747\u4e0d\u7761\u89c9\uff0c\u4e5f\u53ef\u4ee5\u5b58\u6d3b<\/figcaption><p>\u7761\u7720\u662f\u795e\u7ecf\u5143\u6d3b\u52a8\u7684\u7ed3\u679c\uff0c\u56e0\u800c\u591a\u6570\u4eba\u8ba4\u4e3a\u7761\u7720\u5265\u593a\u5bfc\u81f4\u7684\u6b7b\u4ea1\u4e5f\u5e94\u8be5\u662f\u5927\u8111\u529f\u80fd\u53d7\u635f\u7684\u7ed3\u679c\u3002\u8fd9\u9879\u7814\u7a76\u5374\u53d1\u73b0\u7761\u7720\u4e0d\u8db3\u662f\u901a\u8fc7\u80a0\u9053\u4e2dROS\u7684\u7d2f\u79ef\u6765\u5bfc\u81f4\u6b7b\u4ea1\uff0c\u800c\u4e14\u8fd9\u79cd\u6b7b\u4ea1\u53ef\u4ee5\u901a\u8fc7\u4e2d\u548c\u6d3b\u6027\u6c27\uff08\u7ed9\u4e88\u6297\u6c27\u5316\u5242\uff09\u5f97\u4ee5\u907f\u514d\u3002<\/p>\n<p>\u5b9e\u9a8c\u8fc7\u7a0b\u5982\u4e0b\uff1a<\/p>\n<p><b>1.\u4e25\u91cd\u7684\u7761\u7720\u5265\u593a\u4f1a\u5bfc\u81f4\u6b7b\u4ea1\uff1a<\/b>\u7814\u7a76\u53d1\u73b0\uff0c\u679c\u8747\u4e0d\u7761\u89c910\u5929\u5de6\u53f3\u6b7b\u4ea1\u7387\u4f1a\u4e0a\u5347\uff0c\u5e76\u4e14\u572820\u5929\u5185\u5168\u90e8\u6b7b\u4ea1\u3002<\/p>\n<p><b>2.\u679c\u8747\u5728\u6b7b\u4ea1\u65f6\uff0c\u4f53\u5185\u53d1\u751f\u4e86\u4ec0\u4e48\u53d8\u5316\uff1f<\/b>\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u8bd5\u9a8c\u7ec4\u679c\u8747\u7684\u7ec4\u7ec7\u65e0\u635f\u4f24\uff0c\u4f46\u80a0\u9053\u91cc\u5145\u6ee1\u4e86ROS\uff0c\u800c\u4e14\u7761\u7720\u5265\u593a\u6301\u7eed\u8d8a\u4e45\uff0cROS\u7d2f\u79ef\u8d8a\u591a\u3002<\/p>\n<p><img decoding=\"async\" data-src=\"https:\/\/picx.zhimg.com\/50\/v2-e47bfb7d82f80d195eb1007d19fb399c_720w.jpg?source=1def8aca\" src=\"https:\/\/picx.zhimg.com\/50\/v2-e47bfb7d82f80d195eb1007d19fb399c_720w.jpg?source=1def8aca\"\/><figcaption>\u679c\u8747\u80a0\u9053\u5185ROS\u6c34\u5e73\u53d8\u5316<\/figcaption><p><b>3.\u8fd9\u662f\u679c\u8747\u72ec\u6709\u7684\u73b0\u8c61\u4e48\uff1f<\/b>\u7814\u7a76\u8005\u53c8\u9009\u7528\u5c0f\u9f20\u91cd\u590d\u8bd5\u9a8c\u8fc7\u7a0b\uff0c\u540c\u6837\u5730\uff0c\u4e0d\u7761\u89c9\u5c0f\u9f20\u7684\u80a0\u9053\uff08\u5305\u62ec\u5927\u80a0\u548c\u5c0f\u80a0\uff09\u5185ROS\u6c34\u5e73\u4e0a\u5347\uff0c\u4f46\u5728\u5176\u4ed6\u5668\u5b98\u4e2d\u65e0\u6b64\u53d1\u73b0\u3002<\/p>\n<p><img decoding=\"async\" data-src=\"https:\/\/picx.zhimg.com\/50\/v2-8ec0c1d7299089c31be1e4cfc89fdbcd_720w.jpg?source=1def8aca\" src=\"https:\/\/picx.zhimg.com\/50\/v2-8ec0c1d7299089c31be1e4cfc89fdbcd_720w.jpg?source=1def8aca\"\/><figcaption>\u5c0f\u9f20\u5728\u5c0f\u80a0\u548c\u8fbe\u6210\u5185ROS\u6c34\u5e73\u5347\u9ad8<\/figcaption><p><b>4.ROS\u7d2f\u79ef\u4e0e\u679c\u8747\u6b7b\u4ea1\u7684\u5173\u7cfb\uff1f<\/b>\u679c\u8747\u5728\u4e0d\u7761\u89c9\u7684\u7b2c10\u5929\uff0c\u80a0\u9053\u91ccROS\u6c34\u5e73\u8fbe\u5230\u9ad8\u5cf0\uff0c\u8fd9\u662f\u7ec6\u80de\u635f\u4f24\u7684\u6807\u8bb0\uff0c\u7814\u7a76\u8005\u540c\u65f6\u53d1\u73b0DNA\u635f\u4f24\u3001\u538b\u529b\u9897\u7c92\u548c\u7ec6\u80de\u51cb\u4ea1\u540c\u65f6\u5b58\u5728\u3002\u6709\u8da3\u7684\u662f\uff0c\u5982\u679c\u8ba9ROS\u5347\u9ad8\u7684\u679c\u8747\u7ee7\u7eed\u7761\u89c9\uff0c\u679c\u8747\u5c31\u80fd\u6d3b\u4e0b\u6765\uff0c\u800c\u4e14\u80a0\u9053\u5185ROS\u6c34\u5e73\u4f1a\u6062\u590d\u6b63\u5e38\u3002<\/p>\n<p><img decoding=\"async\" data-src=\"https:\/\/picx.zhimg.com\/50\/v2-d0c063daf970d4d451c150ffe03fcd18_720w.jpg?source=1def8aca\" src=\"https:\/\/picx.zhimg.com\/50\/v2-d0c063daf970d4d451c150ffe03fcd18_720w.jpg?source=1def8aca\"\/><\/p>\n<p><b>5.\u7ed9\u4e88\u6297\u6c27\u5316\u5242\u53ef\u4ee5\u62ef\u6551\u679c\u8747\u3002<\/b>\u7814\u7a76\u8005\u7ed9\u4e88\u4e0d\u7761\u89c9\u679c\u8747\u6709\u6548\u7684\u6297\u6c27\u5316\u5242\uff0c\u5305\u62ec\u892a\u9ed1\u7d20\u3001\u786b\u8f9b\u9178\u548cNAD\uff08\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178\uff09\uff0c\u5b9e\u9a8c\u7ed3\u679c\u53d1\u73b0\u53ef\u4ee5\u9006\u8f6c\u679c\u8747\u7684\u6b7b\u4ea1\u3002<\/p>\n<p><img decoding=\"async\" data-src=\"https:\/\/picx.zhimg.com\/50\/v2-c8189628bb6e49694530673120ecf55c_720w.jpg?source=1def8aca\" 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